From the North:
U.S. Highway 277 runs southwest through San Angelo into Del Rio. 2-1/2 hours.
From the West:
Interstate 10 runs through El Paso and connects to U.S. Highway 90, which runs into Del Rio. 8 hours.
From the East:
U.S. Highway 90 runs from San Antonio into Del Rio. 2-1/2 hours.
U.S. Highway Spur 239 begins on the U.S. side of the International Bridge and crosses into Del Rio. 10 minutes.